Минимальный список мутаций генов RAS для тестирования при раке толстой кишки
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Ген
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Мутация
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KRAS (2 экзон)
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c.35G > A (p.Gly12Asp)
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c.35G > T (p.Gly12Val)
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c.35G > C (p.Gly12Ala)
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c.34G > T (p.Gly12Cys)
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c.34G > A (p.Gly12Ser)
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c.34G > C (p.Gly12Arg)
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c.37_38delins2 (p.Gly12Phe)
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c.38G > A (p.Gly13Asp)
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c.38G > C (p.Gly13Ala)
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c.37G > T (p.Gly13Cys)
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c.37G > A (p.Gly13Ser)
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c.37G > C (p.Gly13Arg)
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c.38G > T (p.Gly13Val)
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KRAS (3 экзон)
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c.176C > A (p.Ala59Glu)
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c.176C > G p.Ala59Gly)
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c.175G > T (p.Ala59Ser)
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c.175G > A (p.Ala59Thr)
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c.183A > C (p.Gln61His)
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c.181C > G (p.Gln61Glu)
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c.183A > T (p.Gln61His)
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c.181C > A (p.Gln61Lys)
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c.182A > T (p.Gln61Leu)
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c.182A > C (p.Gln61Pro)
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c.182A > G (p.Gln61Arg)
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KRAS (4 экзон)
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c.351A > C (p.Lys117Asn)
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c.351A > T (p.Lys117Asn)
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c.349A > G (p.Lys117Glu)
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c.350A > G (p.Lys117Arg)
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c.436G > C (p.Ala146Pro)
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c.436G > A (p.Ala146Thr)
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c.437C > T (p.Ala146Val)
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NRAS (2 экзон)
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c.34G > A (p.Gly12Ser)
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c.34G > C (p.Gly12Arg)
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c.34G > T (p.Gly12Cys)
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c.35G > A (p.Gly12Asp)
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c.35G > C (p.Gly12Ala)
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c.35G > T (p.Gly12Val)
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c.37G > A (p.Gly13Ser)
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c.37G > C (p.Gly13Arg)
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c.37G > T (p.Gly13Cys)
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c.38G > A (p.Gly13Asp)
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c.38G > C (p.Gly13Ala)
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c.38G > T (p.Gly13Val)
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NRAS (3 экзон)
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c.175G > A (p.Ala59Thr)
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c.176C > A (p.Ala59Asp)
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c.176C > G (p.Ala59Gly)
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c.175G > T (p.Ala59Ser)
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c.181C > A (p.Gln61Lys)
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c.181C > G (p.Gln61Glu)
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c.182A > G (p.Gln61Arg)
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c.182A > C (p.Gln61Pro)
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c.183A > C (p.Gln61His)
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c.183A > T (p.Gln61His)
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c.182A > T (p.Gln61Leu)
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