Классификация мутаций в гене BRAF
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Мутация
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Класс мутации
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V600 E/K/D/R/L
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1
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T599_V600TinsT
|
2
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T599I/dup/V600insT
|
2
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T599R
|
2
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|
G464 A/E/V/R
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2
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G469 A/V/S/R/L/T170delinsAK
|
2
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V471F
|
2
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K499E
|
2
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F595 L
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2
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L596 Q/R/S/V
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2
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L597 V/S/R/Q/P/K
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2
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I483S
|
2
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L485 F/W
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2
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L485_P490delinsY
|
2
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L505H/F
|
2
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|
L525 R
|
2
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E586K
|
2
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Q257R
|
2
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K601 E/N/Q/T
|
2
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BRAF транслокации
|
2
|
|
A598 V/T599insV
|
2
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N486_P490del
|
2
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|
V487_P492delinsA
|
2
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V600_K601del
|
2
|
|
V600_K601 D/E/N
|
2
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|
V600_K602delinsE
|
2
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V600_K602delinsDT
|
2
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V600_S605delinsEISRWR
|
2
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V600_W604delinsDQTDG
|
2
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G466 E/V/R/A
|
3
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G469 E
|
3
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K483 M/E
|
3
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|
N581 I/S/T/Y/K
|
3
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|
D594 A/H/V/G/N/E/Y/F
|
3
|
|
G596 V/R/C
|
3
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|
F595 L
|
3
|
|
F247 L
|
3
|
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Q524 L
|
3
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R558 Q
|
3
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S467 L
|
3
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T470 R
|
3
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D287H
|
3
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T599A
|
3
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